May 17, 2021
New research papers regarding the iLiNP device are published.
1. Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo.
Journal of Controlled Release 331 (2021) 335–349.
2. Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material.
Pharmaceutics 2021, 13, 544.
March 4, 2021
New research paper regarding the iLiNP device is published.
Title: One-Step Production Using a Microfluidic Device of Highly Biocompatible Size-Controlled Noncationic Exosome-like Nanoparticles for RNA Delivery.
ACS Appl. Bio Mater. 2021, 4, 1783−1793.
January 12, 2021
Lilac pharma and Nippon shokubai starts marketing of ultra-high concentration liposomes for cosmetics.
December 28, 2020
New research paper regarding the iLiNP device is published.
Title: Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition.
J. Control. Release 2020 Dec 14;S0168-3659(20)30736-7.
August 26, 2020
New research paper regarding the iLiNP device is published.
Title: Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery.
ACS Appl. Mater. Interfaces. 2020 Jul 29;12(30):34011-34020.
August 24, 2020
Lilac pharma starts collaboration with the University of Tokyo and kyushu university for development of one-step preparation of the protein-encapsulated PEGylated polyion complex vesicles (PICsome) by the iLiNP microfluidic device.
August 21, 2020
Lilac pharma and Sumitomo Riko succeeded in developing new microfluidic device (tool to manufacture lipid nanoparticles).
June 25, 2019
New research paper regarding the iLiNP device is published.
Title: The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ10 in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria.
J Pharm Sci. 2019 Aug;108(8):2668-2676
March 5, 2019
Lilac pharma starts collaboration with Nippon shokubai for development of liposomes for cosmetics.
