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Nanoparticles manufacturing platform LiNAS-M

By combining the LiNAS-M platform and the dedicated microfluidic chip, you can easily manufacture various kinds of lipid or polymer nanoparticles on your lab bench.

1. Easy to operate even for beginners.
2. Easy to install/uninstall the microfluidic chip.
3. Easy to obtain the nanoparticles suspension whose volume is up to about 5mL/run (when using the 1mL and 5mL syringes).
4. Combination of high-grade pump motor, high-precision glass syringes and accurate inlet/outlet connection mechanism contributes high reproducibility of manufacturing.
5. Efficient nanoparticles formation even at the low flow rate condition (from 0.1 to 1.0mL/min when using the iLiNP-type microfluidic chip) contributes to avoid unexpected or undesired sample consumption especially when preparing small amounts of nanoparticles.
6. No limitation for reuse of the microfluidic chip.

Accessories for the LiNAS-M platform
– iLiNP-type microfluidic chip LM-iLiNP001
– 3 inlet iLiNP-type microfluidic chip LM-iLiNP002
– Straight channel-type microfluidic chip LM-W001
– Plastic case for LM series microfluidic chip

The Straight channel-type chip and the Plastic case are included (one of each) with the purchase of the LiNAS-M main unit.

– Gastight syringe for the syringe pump (1mL, 2.5mL, 5mL)
– Plastic reservoir
– Tubing

Please contact us for details (supplier, spec, etc.)

Assembly of the microfluidic chip

If the microfluidic chip is damaged, only the chip can be replaced.

Installation/Uninstallation of the assembled microfluidic chip

The precise mechanism allows the microfluidic chip to move the proper position and prevents leakage of liquid at the inlets and outlet.


Filling the syringe with the ingredient solutions

Method 1. From the reservoirs.
Once the reservoirs are filled with the ingredient solutions, it is not necessary to remove the syringes for the filling-in process. The solutions are transferred from the reservoirs to the syringes and then discharged to the microfluidic chip automatically.

(the microfluidic chip installed on the right section of the platform is not seen in this video.)(x4 speed)

Method 2. Direct filling
If you want to use various kinds of ingredient solutions 1,2,3,… sequentially, you can fill the syringes 1,2,3,… with each solution, and then the prefilled syringes can be used sequentially. It’s not difficult to remove/attach the syringe from/to the main unit.

Configuration of LiNAS-M + 3 inlet microfluidic chip LM-iLiNP002

Application #1
On-device rapid dilution for further reduction of particle size.

The lipid nanoparticles suspension formed in the iLiNP #1 region is rapidly diluted with water (diluent) in the iLiNP #2 region.
The Rapid dilution will prevent the undesirable aggregation or fusion of lipid nanoparticles even at the high-lipid-concentration condition. This contributes to reduction of the particle size and improvement of the polydispersity index (PDI). (ACS Appl. Mater. Interfaces 2020, 12, 34011−34020.)

Application #2
On-device screening of lipid composition

Lipid mixture solution is prepared in the iLiNP #1 region and then mixed with water (or aqueous drug solution) in the iLiNP #2 region to form lipid nanoparticles. The lipid composition in the lipid mixture can be easily changed by changing the flow rate ratio of lipid solutions (Lipid1, Lipid2). This eliminates the need to exchange the syringe each time, which is necessary for other companies’ products, and contributes to streamline the formulation study. (ACS Appl. Eng. Mater. in press.


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