Products for Overseas
Nanoparticles manufacturing platform LiNAS-M May 2023 New version LM-002 launched!
By combining the LiNAS-M platform and the dedicated microfluidic chip, you can easily manufacture various kinds of lipid or polymer nanoparticles on your lab bench.
The new version LM-002 enables the use of glass syringes and disposable syringes according to the purpose and application.
The use of the glass syringes is recommended if you want to try several pumping conditions using the same raw material solution or if you want to prepare a large quantity of nanoparticles by repeating pumping in combination with using reservoir.
The use of the disposable syringes is recommended if you want to prepare prototype samples using different types of raw material solutions or if want to avoid the hassle of syringe cleaning.
Overall view of LiNAS-M LM-002 (with glass syringe)
A photo when disposable syringe is installed. Syringe replacement is easy.
Features
1. Easy to operate even for beginners.
2. One-click connection of the dedicated microfluidic chip by simply placing it on the tray and turning the handle.
3. High reproducibility of nanoparticle production is achieved by using a high-precision pump.
4. High flexibility of piping allows customers to easily customize the pumping route.
5. Unlimited use of the dedicated microfluidic chip.
6. Easy to control particle size by using iLiNP type microfluidic chip (patented technology).
7. Flexibility to change the shape of the flow channel.
The LiNAS-M LM-002 is the ideal unit (platform) for customers who want to experiment with various methods of making nanoparticles easily and reproducibly.
Microfluidic chips and plastic case for the LiNAS-M platform
– iLiNP-type microfluidic chip LM-iLiNP001(standard channel), LM-iLiNP003(wide channel)
– 3 inlet iLiNP-type microfluidic chip LM-iLiNP002
– Straight channel-type microfluidic chip LM-W001
– Plastic case for LM series microfluidic chip
Solvent resistance is based on the solvent resistance of PDMS, which is the material of the microfluidic chips. We recommend the use of water and alcohols as solvents.
Microfluidic chips specification table
Channel shape (schematic)
LM-iLiNP001(standard), LM-iLiNP003(wide)
LM-iLiNP002
LM-W001
Other consumables
– Syringes (see below)
– Tubings
– Fittings
Please contact us for details.
Assembly of the microfluidic chip
If the microfluidic chip is damaged, only the chip can be replaced.
Installation/Uninstallation of the assembled microfluidic chip
The precise mechanism allows the microfluidic chip to move the proper position and prevents leakage of liquid at the inlets and outlet.
Filling the syringe with the ingredient solutions
Method 1. From the reservoirs (Available only when glass syringe is installed.)
Once the reservoirs are filled with the raw material solutions, it is not necessary to remove the syringes for the filling-in process. The solutions are transferred from the reservoirs to the syringes and then discharged to the microfluidic chip.
(the microfluidic chip installed on the right section of the platform is not seen in this video.)(x4 speed)
Method 2. Direct filling
If you want to use various kinds of raw material solutions 1,2,3,… sequentially, you can fill the syringes 1,2,3,… with each solution, and then the prefilled syringes can be used sequentially. It’s not difficult to remove/attach the syringe from/to the main unit.
(Wash the feed line and the microfluidic tip each time as needed.)
Configuration of LiNAS-M + 3 inlet microfluidic chip LM-iLiNP002
Application #1
On-device rapid dilution for further reduction of particle size.
The lipid nanoparticles suspension formed in the iLiNP #1 region is rapidly diluted with water (diluent) in the iLiNP #2 region.
The Rapid dilution will prevent the undesirable aggregation or fusion of lipid nanoparticles even at the high-lipid-concentration condition. This contributes to reduction of the particle size and improvement of the polydispersity index (PDI). (ACS Appl. Mater. Interfaces 2020, 12, 34011−34020.)
Application #2
On-device screening of lipid composition
Lipid mixture solution is prepared in the iLiNP #1 region and then mixed with water (or aqueous drug solution) in the iLiNP #2 region to form lipid nanoparticles. The lipid composition in the lipid mixture can be easily changed by changing the flow rate ratio of lipid solutions (Lipid1, Lipid2). This eliminates the need to exchange the syringe each time, which is necessary for other companies’ products, and contributes to streamline the formulation study. (ACS Appl. Eng. Mater. in press. https://doi.org/10.1021/acsaenm.2c00062)
